Kisspeptin-10 (10mg)

$32.00

Category: Research Peptides Vials

Description
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Kisspeptin-10 (10mg) For Sale

Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the KISS1 gene product, ending in the RFamide motif shared across the kisspeptin family. It is supplied as a lyophilized powder in a 10mg vial for laboratory use. The compound is characterized in research on KISS1R (GPR54) signaling and in cell models of migration, invasion, and neuronal response. Every batch is third-party tested for identity and purity and supplied for research use only.

Kisspeptin-10 Product Description

Kisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal 45-54 fragment of the KISS1 gene product. It carries the sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ and ends in a C-terminal amide that defines the kisspeptin RFamide family.

It is the shortest member of the kisspeptin family that retains binding activity at its cognate receptor, KISS1R, also designated GPR54. Longer family members include kisspeptin-54, kisspeptin-14, and kisspeptin-13, all of which share the same C-terminal decapeptide.

The compound is produced through controlled peptide synthesis and supplied as a lyophilized powder for stability during storage and handling. It is characterized in laboratory research on neuroendocrine signaling and cell-motility pathways.

Compound Information

Property	Value
CAS Number	374675-21-5
PubChem CID	25240297
Molecular Formula	C₆₃H₈₃N₁₇O₁₄
Molecular Weight	1302.5 g/mol
Monoisotopic Mass	1301.63 Da
Amino Acid Sequence	Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF-NH₂)
Sequence Length	10 residues (decapeptide)
InChIKey	RITKWYDZSSQNJI-INXYWQKQSA-N
Source	Synthetic
Synonyms	KP-10, Metastin (45-54), KiSS-1 (45-54)
Purity	≥99% (HPLC)
Appearance	Lyophilized white powder
Solubility	Soluble in water; bacteriostatic water for reconstitution
Storage	-20°C, protect from light

Storage and Handling

Store the lyophilized compound at -20°C, protected from light.
After reconstitution, store at 2-8°C and use promptly.
Maintain aseptic handling to preserve compound integrity.

Lyophilized Format

This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.

Product Usage

This product is intended as a research chemical only. This designation allows use strictly for in vitro testing and laboratory experimentation. All product information on this website is for educational purposes only. This product should be handled only by licensed, qualified professionals. It is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled.

Research Applications

Research Area	In Vitro Application
Receptor signaling	Characterization of KISS1R (GPR54) binding and downstream ERK1/2 activation in receptor-expressing cell lines
Cell motility	Study of migration and invasion pathways in trophoblast-derived cell models
Extracellular matrix	Investigation of matrix metalloproteinase and tissue inhibitor expression in fibroblast cultures
Neuronal models	Examination of α-synuclein-linked apoptosis in SH-SY5Y-derived neurons
Radiolabeling chemistry	Evaluation of chelator-conjugated analogues for receptor-targeted imaging research

What Research Shows

Kisspeptin-10 is the shortest fragment of the kisspeptin family that binds KISS1R (GPR54). Research on the KiSS-1/GPR54 system has mapped its signaling across reproductive regulation and metastasis-related pathways in a range of cell and animal models [1].

In receptor-transfected cell systems, kisspeptin-10 and a DOTA-conjugated analogue produced comparable KISS1R activation, measured by inositol phosphate accumulation in KISS1R-expressing HEK293 cells. The conjugate retained receptor functionality and was characterized for its serum stability period [2].

These findings anchor several distinct research threads, from cell motility to neuronal and cardiac models.

Cell Motility and Signaling Models

In the HTR8SVneo placental cell line, kisspeptin-10 was associated with reduced cell migration through an ERK1/2-p90rsk-GSK3β-FAK signaling feedback loop [3].

In first-trimester trophoblast cultures, KP-10 raised intracellular calcium and was characterized as an inhibitor of cell motility without changing proliferation [4]. Related in vitro work reported altered expression of matrix metalloproteinases, their tissue inhibitors, and VEGF-A downstream of KISS1R and ERK1/2 [5]. These reproductive-model studies sit alongside other neuroendocrine research compounds in the catalog.

Neuronal and Cardiac Fibroblast Models

In choline acetyltransferase-positive SH-SY5Y neurons engineered to overexpress wild-type or E46K mutant α-synuclein, kisspeptin-10 was associated with reduced α-synuclein-linked apoptosis and mitochondrial depolarization, in a KISS1R-independent manner [6].

In cardiac fibroblast cultures, kisspeptin-10 was associated with changes in intracellular collagen content and focal adhesion kinase phosphorylation, alongside shifts in matrix metalloproteinase and tissue inhibitor release [7].

Certificate of Analysis (COA) for Every Batch

A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

High-performance liquid chromatography (HPLC) for purity, typically confirmed at 99% or higher
Liquid chromatography mass spectrometry (LC-MS) for molecular identity and mass confirmation
Sterility and endotoxin screening where applicable
Chemical contaminant and residual solvent checks

COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.