N-Acetyl Semax Amidate (20mg) For Sale

N-Acetyl Semax Amidate Product Description

N-Acetyl Semax Amidate is a stabilized synthetic peptide variant engineered through N-terminal acetylation and C-terminal amidation to resist enzymatic degradation and extend biological activity. This modification replaces the original peptide’s terminal carboxylic acid (-COOH) with an amide group (-NH₂), enhancing its stability. 

Structurally defined as Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂, it demonstrates prolonged half-life (~30 minutes longer than standard Semax) and increased neuroprotective efficacy, modulating neurotransmitters like serotonin and dopamine and upregulating BDNF expression. Preclinical studies highlight its potential in cognitive enhancement, neuroregeneration, and therapeutic applications for stroke or neurodegenerative disorders.

Peptide Information

N-Acetyl Semax Research

N-Acetyl Semax is a synthetic heptapeptide demonstrating neuroprotective and cognitive-enhancing properties. Research indicates its potential in preventing amyloid beta aggregation, providing neuroprotection in ischemic conditions, and enhancing learning and memory functions. The peptide achieves these effects through modulation of neurotransmitter systems and regulation of inflammatory responses, while also showing promise in stress response and immune system function.

Neuroprotective and Cognitive Effects

Semax has been shown to prevent the formation of amyloid beta (Aβ) complexes with copper ions, which are implicated in Alzheimer’s disease, inhibiting fibrillogenesis and providing protective effects against neurodegeneration.¹

The peptide has additionally been found to exert neuroprotective effects in the context of ischemic brain conditions. It enhances angioprotective, antihypoxic, and neurotrophic activities, which are crucial during the acute period of ischemic stroke. Furthermore, Semax administration has been associated with the modulation of inflammatory responses, promoting anti-inflammatory agents over pro-inflammatory factors, which is beneficial in post-ischemic conditions.²

Semax is recognized for its nootropic effects, which include improvements in cognitive functions such as learning and memory. In animal models, Semax has been shown to enhance cognitive recovery in cases of chronic brain ischemia, particularly when used in combination with hopantenic acid.³

The mechanisms underlying the potential cognitive and neuroprotective effects of Semax involve its interaction with various neurotransmitter systems and neurotrophic factors. Semax modulates monoaminergic systems, particularly serotonin and dopamine, which are crucial for mood regulation and cognitive functions. Semax increases serotonin turnover and enhances dopamine release, which can improve learning and memory.⁴

Moreover, Semax has been observed to increase brain-derived neurotrophic factor (BDNF) levels in the basal forebrain, a region associated with cognitive functions, further supporting its role in enhancing cognitive abilities.⁵

Semax and Alzheimer’s Disease (AD)

Semax is an ACTH-like peptide that has shown the ability to form stable complexes with Cu2+ ions. This property is crucial as it helps prevent the formation of Aβ:Cu2+ complexes, which are implicated in the pathogenesis of AD. Studies have demonstrated that Semax can inhibit fibrillogenesis, particularly the formation of oligomeric species, thereby exhibiting anti-aggregating properties.¹

Research has indicated that Semax can enhance the survival of cholinergic neurons in the basal forebrain, which are known to degenerate in Alzheimer’s dementia. In vitro studies have shown that Semax can increase the survival rate of these neurons by approximately 1.5-1.7 fold and stimulate the activity of choline acetyltransferase, an enzyme critical for acetylcholine synthesis.⁶

While the exact implications of Semax in Alzheimer’s disease require further clarification, its ability to modulate Aβ aggregation and support neuronal survival presents a promising avenue for therapeutic development. Continued research is necessary to explore the full potential of Semax, including its delivery methods and efficacy in clinical settings.

Semax and Stress Response

Semax has demonstrated significant immunomodulatory properties in models of “social” stress. It effectively restores cellular and humoral immune responses, as well as the phagocytic activity of neutrophils, indicating its potential as an immune corrector under stress conditions⁷. Additionally, Semax helps in normalizing the levels of pro- and anti-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, which are typically elevated under stress.⁸

Research indicates that Semax can block the opioid form of stress-induced analgesia (SIA) without affecting behavioral changes in rats exposed to acute stressors such as inescapable foot shock and forced cold-water swim stress. This suggests that while Semax can modulate pain sensitivity under stress, it does not alter stress-induced behavioral responses.⁹

In conditions of informational and social stress, Semax exhibits stress-protective effects by reducing stress-induced physiological changes, such as adrenal hypertrophy and gastric mucosa lesions. It also shows antioxidant properties by decreasing lipid peroxidation in immunocompetent organs like the thymus and spleen, thereby mitigating stress-induced immune dysfunction.¹⁰

Immune and Vascular System Modulation

In a study on rat brain focal ischemia, Semax was found to enhance the expression of genes related to the immune system, particularly those encoding immunoglobulins and chemokines, which are crucial for immune cell activity and mobility.¹¹ This immunomodulatory effect was further supported by research demonstrating Semax’s ability to restore cellular and humoral immune responses and phagocytic activity of neutrophils under “social” stress conditions, indicating its potential as an effective immune corrector.⁷

In addition to its effects on the immune system, Semax also modulates the vascular system. In ischemic conditions, Semax altered the expression of genes associated with the development and migration of endothelial tissue, smooth muscle cell migration, hematopoiesis, and vasculogenesis.¹¹

Certificate of Analysis (COA) for Every Batch

A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

• High-performance liquid chromatography (HPLC) for purity, typically confirmed at 99% or higher
• Liquid chromatography mass spectrometry (LC-MS) for molecular identity and mass confirmation
• Sterility and endotoxin screening where applicable
• Chemical contaminant and residual solvent checks

COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.