NAD+ (500mg) For Sale

NAD+ Product Description

NAD+ is a coenzyme involved in redox reactions and cellular metabolism. It has gained attention for its role as a signaling molecule, influencing processes such as energy metabolism, cell survival, and aging. NAD+ levels decline with age, leading to altered metabolism and increased disease susceptibility, which has spurred interest in NAD+-boosting molecules to enhance health and longevity.

Product Information

NAD+ Research

NAD+ is involved in redox reactions and serves as a cofactor for various enzymes, including sirtuins and poly(ADP-ribose) polymerases. It plays a significant role in cellular processes such as metabolism, DNA repair, and chromatin remodeling, which are vital for maintaining tissue and metabolic homeostasis. A decline in NAD+ levels is observed with aging, contributing to age-associated diseases like cognitive decline, cancer, and metabolic disorders.

Aging and Longevity

NAD+ plays a significant role in aging and longevity. Research indicates that restoring NAD+ levels in aged or diseased animals can promote health and extend lifespan. This has led to the exploration of NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which have shown promise in ameliorating age-associated pathophysiologies.¹

CD38, an NADase, plays a central role in age-related NAD+ decline. Inhibiting CD38 with specific inhibitors like 78c has been shown to reverse NAD+ decline and improve metabolic and physiological parameters in aging models. This includes enhanced glucose tolerance, muscle function, and cardiac performance. The increase in NAD+ levels activates pro-longevity factors such as sirtuins and AMPK, while inhibiting pathways like mTOR-S6K that negatively affect healthspan. This pharmacological strategy highlights the potential of targeting NAD+ metabolism to prevent or reverse age-related metabolic dysfunction.²

Metabolic Disorders

Alterations in NAD+ metabolism are closely linked to the development of metabolic disorders such as diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). NAD+ levels tend to decrease with aging and under conditions of nutrient disturbance, contributing to these disorders.³ The imbalance in NAD+/NADH ratios can lead to impaired cellular stress responses and metabolic dysfunctions, which are characteristic of metabolic diseases.⁴

Cardiovascular Diseases

Aging and metabolic stress are associated with a decline in NAD+ levels, which can lead to mitochondrial dysfunction and increased susceptibility to cardiovascular diseases.⁵ This depletion is linked to major risk factors such as obesity and hypertension, which contribute to the development of conditions like atherosclerosis and cardiomyopathies.⁶ The loss of NAD+ with age or stress underscores the importance of maintaining NAD+ levels to prevent cardiovascular dysfunction.⁷

Neurodegenerative Disorders

NAD+ participates in redox reactions and NAD+-dependent signaling processes, which are essential for modulating mitochondrial function and reducing oxidative stress, a common feature in neurodegenerative diseases. The activation of NAD+-dependent pathways can enhance cellular resilience against oxidative damage, which is crucial for maintaining neuronal health.⁸ Additionally, NAD+ influences axonal maintenance and viability, with its metabolism being a target for therapeutic interventions in neurological diseases.⁹

Research suggests that increasing NAD+ availability can ameliorate mitochondrial dysfunction and reduce neuroinflammation. This has been demonstrated in models of Parkinson’s disease, Alzheimer’s disease, and ALS, where NAD+ enhancement improved mitochondrial function, reduced neuroinflammation, and enhanced cognitive and synaptic functions. The Sirt1/PGC-1α pathway is one mechanism through which NAD+ exerts its protective effects, highlighting its potential as a therapeutic target.¹⁰

Mitochondrial Function

NAD+ metabolism is intricately linked to mitochondrial function. It acts as a substrate for sirtuins, a family of NAD+-dependent deacylases, which are key regulators of mitochondrial homeostasis. Increased NAD+ levels and sirtuin activation have been associated with improved mitochondrial function, organismal metabolism, and lifespan across various species.¹¹

The source and transport of NAD+ within mitochondria have been subjects of debate. Recent studies have identified SLC25A51 as a mammalian mitochondrial NAD+ transporter, which is essential for maintaining mitochondrial NAD+ pools and respiratory function.¹² The de novo synthesis of NAD+ has been shown to enhance mitochondrial function, with enzymes like ACMSD playing a critical role in regulating cellular NAD+ levels and sirtuin activity.¹¹

Cancer Research

Cancer cells exhibit a unique metabolic phenotype known as the Warburg effect, characterized by increased glycolysis even in the presence of oxygen, which is supported by elevated NAD+ levels.¹² The NAD+ salvage pathway is particularly important in cancer cells, as it is the primary method of NAD+ synthesis, and its inhibition has been shown to induce cancer cell cytotoxicity.¹³

NAD+ metabolism is not only crucial within cancer cells but also affects the tumor microenvironment. NAD+ and its metabolites can influence immune responses and contribute to the creation of an immunosuppressive tumor microenvironment.¹⁴ Enzymes such as CD38, which consume NAD+, are involved in producing immunosuppressive metabolites like adenosine, further impacting cancer progression and immune evasion.¹⁵

Targeting NAD+ metabolism presents a promising strategy for cancer treatment. Inhibitors of NAD+ biosynthesis, particularly those targeting nicotinamide phosphoribosyltransferase (NAMPT), have shown potential in preclinical models, although resistance mechanisms such as alternative NAD+ biosynthetic pathways can limit their effectiveness.¹⁶

Certificate of Analysis (COA) for Every Batch

A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

• High-performance liquid chromatography (HPLC) for purity, typically confirmed at 99% or higher
• Liquid chromatography mass spectrometry (LC-MS) for molecular identity and mass confirmation
• Sterility and endotoxin screening where applicable
• Chemical contaminant and residual solvent checks

COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.